Prediction of non-genotoxic carcinogenicity based on genetic profiles of short term exposure assays

Non-genotoxic carcinogens are substances that induce tumorigenesis by non-mutagenic mechanisms and long term rodent bioassays are required to identify them. Recent studies have shown that transcription profiling can be applied to develop early identifiers for long term phenotypes. In this study, we used rat liver expression profiles from the NTP (National Toxicology Program, Research Triangle Park, USA) DrugMatrix Database to construct a gene classifier that can distinguish between non-genotoxic carcinogens and other chemicals. The model was based on short term exposure assays (3 days) and the training was limited to oxidative stressors, peroxisome proliferators and hormone modulators. Validation of the predictor was performed on independent toxicogenomic data (TG-GATEs, Toxicogenomics Project-Genomics Assisted Toxicity Evaluation System, Osaka, Japan). To build our model we performed Random Forests together with a recursive elimination algorithm (VarSelRF). Gene set enrichment analysis was employed for functional interpretation. A total of 770 microarrays comprising 96 different compounds were analyzed and a predictor of 54 genes was built. Prediction accuracy was 0.85 in the training set, 0.87 in the test set and increased with increasing concentration in the validation set: 0.6 at low dose, 0.7 at medium doses and 0.81 at high doses. Pathway analysis revealed gene prominence of cellular respiration, energy production and lipoprotein metabolism. The biggest target of toxicogenomics is accurately predict the toxicity of unknown drugs. In this analysis, we presented a classifier that can predict non-genotoxic carcinogenicity by using short term exposure assays. In this approach, dose level is critical when evaluating chemicals at early time points.Fil: Perez, Luis Orlando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico para el Estudio de los Ecosistemas Continentales; ArgentinaFil: González José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico para el Estudio de los Ecosistemas Continentales; ArgentinaFil: Peral Garcia, Pilar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria ; Argentin

Propuesta para alfabetizar en televisión a familias vulnerables de Colombia

Actualmente, la sociedad concibe la televisión como un punto de encuentro entre la tecnología del siglo XX y el ritmo vertiginoso del siglo XXI. En este sentido, este estudio aborda la evolución del mar de pantallas y sus múltiples contenidos, que inundan continuamente los hogares, y cuyo fin es analizar la repercusión mediática de los espectadores en el pensamiento crítico de sus elecciones audiovisuales. Por lo tanto, este trabajo presenta una propuesta de alfabetización mediática dirigida a favorecer el conocimiento, uso y recepción de la televisión en las familias del municipio de Villa del Rosario en Colombia, con el objetivo de establecer las pautas correctas para que familias de bajos recursos puedan consumir de forma adecuada la televisión. Mediante la revisión teórica e investigativa se conceptualizan los temas y contextos centrales asociados con el proyecto para generar un análisis crítico, que permita establecer los criterios claves del proceso. Asimismo, el proyecto está desarrollado a través de una metodología mixta de investigación participativa, permitiendo una mejor aproximación al objeto de estudio y apuntando al desarrollo social y el fortalecimiento de la calidad de vida. Por lo tanto, para llevar a cabo este estudio se realizó un Focus Group con una muestra total de 20 padres divididos en dos grupos focales con la finalidad de conseguir una mejor percepción por parte de los participantes. Además, se emitió una encuesta a un total de 100 personas, para la recolección de datos y fortalecer la veracidad de los hallazgos identificados dentro de los patrones de consumo televisivo. Entre los resultados obtenidos destaca la disposición de la comunidad por participar en este tipo de proyectos y el papel notorio que mantiene la televisión dentro de la unidad familiar. Además, conseguimos establecer las pautas específicas para enseñar televisión, determinando el análisis crítico, la reflexión y las competencias concedidas frente al medio de comunicación frente a la mirada crítica del espectador en riesgo de inclusión social

A Comparative Study Of Grades 10 And 11 Students’ Perceptions Of English Teacher Effectiveness In Lai Za High School And Mai Ja Yang High School In Kachin State, Myanmar

The purpose of this study was twofold: firstly, to determine Grades 10 and 11 students’ perceptions of English teacher effectiveness using Danielson’s (2011) framework for teaching model and its domains (i.e., planning and preparation, classroom environment, and instruction) in Lai Za High School and Mai Ja Yang High School in Kachin State, Myanmar; and secondly, to identify whether there were significant differences in Grade 10, Grade 11, and Grades 10 and 11 students’ perceptions of English teacher effectiveness between the same schools. This quantitative study used the Students’ Perceptions of Teacher Effectiveness Questionnaire (SPTEQ, Sprague, 2013). The respondents were 184 Grades 10 and 11 students in Lai Za High School and 220 Grades 10 and 11 students in Mai Ja Yang High School during the academic year 2017-2018. The research findings indicated that, in Lai Za High School, on average, Grade 10 students perceived their English teachers as neither effective nor ineffective, while Grade 11 students perceived their English teachers as effective. In Mai Ja Yang High School, both Grades 10 and 11 students, on average, perceived their English teachers as effective. Independent samples t-tests revealed that there were significant differences in Grade 10 and Grades 10 and 11 students’ perceptions of English teacher effectiveness between Lai Za High School and Mai Ja Yang High School, whereas no significant difference in Grade 11 students’ perceptions of English teacher effectiveness was noted between Lai Za High School and Mai Ja Yang High Schoo

A Qualitative Case Study on the Challenges of Acs Wasc Accreditation Preparation in King Mongkut’s International Demonstration School

The aim of this research study was to identify the challenges of King Mongkut’s International Demonstration School (KMIDS) on the Accrediting Commission for Schools, Western Association of Schools and Colleges (ACS WASC) accreditation preparation, from the perspective of school administrators, school supervisor, ACS WASC coordinators and teachers. For this purpose, the researchers built and implemented an in-depth, structured interview protocol, which was conducted one-on-one with 17 participants. Member-checking and triangulation techniques were used in combination with notes from the observations and document reviews in order to ensure internal validity. The researchers applied a systematic qualitative design, consisting of open coding, axial coding, and selective coding, to analyze and interpret the collected data. Such inductive and deductive qualitative process led to the identification of 14 themes and 24 sub-themes oriented around the six categories of ACS WASC initial visit framework. Regarding “Organization for student learning”, there were four main challenges and eight sub-challenges found. Regarding “Curriculum, instruction and assessment”, there were two main challenges and six subchallenges found. Regarding “Support for student personal and academic growth”, there were two main challenges and two sub-challenges found. Regarding “Resource management and development”, there were one challenge and two sub-challenges found. Regarding “ONESQA standards for Thai language and Thai studies”, there were two main challenges and two sub-challenges found. Regarding “Boarding program”, there were three challenges found. Finally, recommendations for different stakeholders in relation to the six categories of ACS WASC initial visit framework, as well as for future researchers, are presented

Acuerdo bilateral entre Colombia y Estados Unidos para la entrega de nacionales por comisión de conductas delictivas dentro del marco de cooperación internacional: análisis sobre la pérdida de la proporcionalidad y reciprocidad

Artículo de reflexiónUna vez se configura el tratado de extradición en el derecho internacional, se puede identificar características particulares que se presentan. En los acuerdos de extradición que han surgido entre Colombia y los Estado Unidos, que formalmente iniciaron una serie de obligaciones capaces de describir el origen teleológico de dichos acuerdos, permite concluir respondiendo, si los tratados internacionales que regulan la extradición entre estos dos países se presentan como mecanismo de cooperación o como un instrumento de la política norteamericana para asegurar sus proyecciones nacionales e internacionales.PregradoAbogad

A Comparative Study of Grade 6 Students’ Academic Achievement and Motivation for Learning English as a Foreign Language Under Cooperative Teaching Method and Traditional Teaching Method at Watbangchalongnai School, Samut Prakan, Thailand

The purpose of this study was to find if cooperative teaching methods in Watbangchalongnai School, Samut Prakan, Thailand, would enhance Grade 6 students’ English academic achievement, measured by their abilities in grammar, reading comprehension, and vocabulary. The study also sought to measure students’ motivation for learning English as a foreign language (EFL). For the purpose of the study, the researcher conducted an intervention experiment for 12 weeks, from December 2018 to March 2019, in which two intact Grade 6 groups were chosen, one as experimental group and the other as control group. During the experiment, subjects in the experimental group (39 students) attended classes based on cooperative teaching method. The control group (39 students), on the other hand, did not carry out any additional activities to traditional teaching method. To control as many variables as possible, the number of classes per week, duration of each class and components to be taught were all the same in both groups. In order to test the effectiveness of such strategy, two quantitative tools for data collection were used to compile the findings of the study. To begin with, a pre-test and a post-test were administered to measure students’ academic achievement in learning EFL before and after the treatment. Afterwards, a questionnaire was distributed to both groups in order to measure students’ motivation for learning EFL. The results of the independent samples t-test on a difference of academic achievement revealed a significant difference between the two groups. The sample means showed that subjects in the experimental group increased their academic achievement from the pre-test to the post-test significantly more than subjects in the control group. Results regarding motivation for learning EFL failed to reveal a significant difference between the two groups. The sample means showed that subjects in the experimental group demonstrated high mean scores on motivation for learning EFL, which were statistically similar to those shown by subjects in the control group. Based on the research findings, recommendations for students, teachers, administrators and future researchers are provided

The National Army As Organization With Social Corporate Responsibility In The Post-Conflict

32 páginas : fotos, imágenes.La responsabilidad social empresarial es una nueva tendencia en el mundo de los negocios, que tiene como finalidad generar valor agregado a los productos o servicios de las organizaciones, mediante una retribución a la sociedad por los recursos y beneficios recibidos del entorno, lo que de cierta manera puede verse como una ventaja competitiva en un nicho de mercado. Ahora bien, el Ejército Nacional de Colombia como organización, conformada por un aproximado de 445.000 efectivos, puede ser considerada como una de las organizaciones empresariales más grandes del país, la cual ha tenido que enfrentar contantes cambios organizacionales y misionales según las exigencias del orden público nacional, hecho que no le ha permitido abarcar otro aspecto importante de sus misión como institución instaurada para servir y proteger al pueblo colombiano, este aspecto es la responsabilidad social empresarial o también llamada responsabilidad corporativa, la cual es realizada por las organizaciones para contribuir con el desarrollo de un país.Tabla de contenido Objetivo General 3 Objetivos Específicos. 3 Pregunta Problema 3 Resumen 4 Abstract 4 Palabras Clave 5 Introducción 6 Marco teórico 7 El Término Responsabilidad Social Corporativa 7 Historia Y Evolución De La Responsabilidad Social Empresarial 4 Desarrollo 12 Visión del Comandante del Ejército Nacional para Implantar La (RSE) a la Proyección Estratégica del Ejército Multimisión. 12 Acción Integral 14 Departamento de Acción Integral y Desarrollo (CEDE9) 16 Dirección de Operaciones de Información 17 Dirección de Consolidación Regional y Local 17 Dirección Administrativa de Acción Integral 17 El departamento de ingenieros militares (CEDE10). 17 Conclusiones. 27 Bibliografía. 31The corporate social responsibility is a new trend in the business world. This has as purpose to generate value added to the products and services of the organizations. By means of remuneration to the company for the resources and benefits received of the environment. What of certain way can turns as a competitive advantage in a niche of market. Now then. The National Army of Colombia as organization. It shaped for brought near of 445.000 workforces, can be considered to be one of the biggest managerial organizations of the country, which has had to face constants organizational changes and missions according to the requirements of the public national. Made order that has not allowed him to include another important aspect of his mission as institution restored to serve and to protect the Colombian people, this aspect is the social managerial responsibility or also called corporate responsibility, which is realized by the organizations to contribute with the development of a country

A Comparative Study of Teachers’ and Students’ Beliefs Towards Teacher- Centered and Learner-Centered Approaches in Grade 12 English as a Foreign Language Class at One Governmental Senior Secondary School In Shaan’xi Province, China

The aim of this study was to determine what were Grade 12 EFL teachers’, and Grade 12 intermediate- and advanced-level students’ beliefs towards teacher-centered approach and learnercentered approach, in order to determine whether there was a significant difference between them. This study was conducted at one governmental senior secondary school in Shaan’xi Province, China. The study focused on 23 Grade 12 EFL teachers, 48 Grade 12 EFL intermediate-level students and 87 Grade 12 EFL advanced-level students of the second semester of academic year 2016-2017 from the target school. The researchers used descriptive and inferential statistics to analyze the data. Among other things, the research findings presented here showed that teachers hold positive beliefs towards both teacher-centered approach and learner-centered approach; both intermediate-level students and advanced-level students hold neutral beliefs towards teacher-centered approach and learner-centered approach, and positive beliefs towards teacher-centered approach and learner-centered approach. The results of the study also showed that there was a significant difference between Grade 12 teachers’ beliefs and Grade 12 intermediate- and advanced-level students’ beliefs towards teacher-centered approach and learner-centered approach in EFL class at the target school, whereas there was no significant difference between Grade 12 EFL intermediate-level and advanced-level students’ beliefs towards both teacher-centered approach and learner-centered approach in EFL. Based on these findings, the researchers gave some suggestions to students, teachers, administrators and future researchers

A Correlational Study of Self-Efficacy and Perceived Parental Encouragement for Learning English as a Foreign Language with English Academic Achievement of Batch 5 and Batch 6 Students at Level Up Academy, Loikaw Township, Kayah State, Myanmar

Abstract: The purpose of this quantitative study was to investigate if there was a significant relationship of self-efficacy and perceived parental encouragement for learning English as a foreign language with English academic achievement of Batch 5 and Batch 6 students at Level Up Academy, Loikaw Township, Kayah State, Myanmar. A population sample of 71 students from Batch 5 (34 students) and Batch 6 (37 students), enrolled during the academic year 2017-2018, was chosen for this study. A 32-item questionnaire was used to measure the levels of self-efficacy for learning EFL, including its four subscales (listening efficacy, speaking efficacy, reading efficacy and writing efficacy); an 8-item questionnaire was used to measure perceived parental encouragement for learning EFL; and the levels of English academic achievement were determined using the English subject’s final test. After data collection was done, descriptive statistics (means and standard deviations) and a statistical hypothesis testing (correlational analysis using Pearson’s product moment correlation and multiple correlation coefficient) were carried out to address the research objectives and hypotheses of this study. The research findings indicated that the levels of self-efficacy for learning EFL of both Batch 5 and Batch 6 students were slightly high. It was also found that the level of perceived parental encouragement of Batch 5 students was slightly high, while that of Batch 6 students was moderately high. The English subject’s final test revealed that Batch 5 and Batch 6 students had good English academic achievement. Correlational analysis using Pearson’s product moment correlation suggested that there was a strong, significant and positive relationship of self-efficacy for learning EFL with English academic achievement of Batch 5 and Batch 6 students. However, there was not significant relationship of perceived parental encouragement for learning EFL with English academic achievement of Batch 5 and Batch 6 students. The four subscales of self-efficacy for learning EFL (listening, speaking, reading and writing efficacy) were also strongly, positively and significantly correlated with English academic achievement of Batch 5 and Batch 6 student Level Up Academy, Loikaw Township, Kayah State, Myanmar

A Correlational-Comparative Study of Perception of ICT Use in the Classroom and Academic Achievement of Grades 3 and 4 Students in Chinese Language Class at Prasarnmit Primary School International Program in Bangkok, Thailand

This study was conducted to identify whether there was a significant difference in perception of ICT use in the classroom between Grades 3 and 4 students learning Chinese as a foreign language at Prasarnmit Primary School International Program (PPiP) in Bangkok, Thailand. Also, this study examined the relationship between the perception of ICT use in the classroom held by these students and their academic achievement in Chinese language class. ICT Use in Learning Chinese Questionnaire, comprised of 13 items using a 5-point Likert scale, was used for measuring the level of perceptions of ICT use in the classroom. Forty-eight students participated in this study, conducted during the academic year 2018-2019. The research findings showed that Grade 3 students held, on average, a moderate perception of ICT use in the classroom in Chinese language class, while Grade 4 students held a positive perception instead. The study also showed that the level of academic achievement of Grade 3 students in Chinese language class was satisfactory, while for Grade 4 students was fairly good. The results showed that there was no significant relationship between perception of ICT use in the classroom and academic achievement of both Grades 3 and 4 students in Chinese language class at PPiP. Also, there was no significant difference in perception of ICT use in the classroom between Grades 3 and 4 students in Chinese language class at PPiP